Barbra Streisand Shamelessly Asks Melissa McCarthy About Ozempic Use

Barbra Streisand is feeling the heat due to her social media activity.

After Melissa McCarthy shared photos of her and director Adam Shankman in an April 29 Instagram post, Barbra added a comment that raised more than a few eyebrows.

In her caption, Melissa called out her gorgeous, all-pastel green look for LA's Center Theatre Group Gala, writing, "Pastels only to honor the incredible @matthewbourne13 at the @ctgla gala last night with this fella @adamshankman !! Thiiiiis much closer to my dream of dancing on stage"

Many stars in the comments gushed over the look, including Octavia Spencer, who wrote, "These lewks are yummy." However, in a since-deleted, though much screen-shotted, comment Barbra chimed in, "Give him my regards did you take Ozempic?"

And fans were quick to call out the very direct question.

"Babs. No, honey. Just no," wrote one user, while another added, "Rude, Barbra."

Others, however, came to Barbra's defense, noting it was possible the 82-year-old didn't realize she was leaving her question on such a public forum. 

"I think Barbara thought it was a dm," commented one user, while another passionately added, "Leave Barbara alone she would never do that on purpose I believe she meant that for a private question. Cant any of you show her some grace !!"

E! News has reached out to reps for Barbra and Melissa for comment but has not yet heard back. 

Accident or not, Barbra is just one in a now long line of celebrities to find themselves at the center of conversations about the type 2 diabetes drug that found new life as a method for weight loss. 

Recently Jon & Kate Plus 8's Jon Gosselin gave his two cents about the medical craze after he revealed he lost 32 pounds using Ozempic. 

"You know what's annoying?" the 47-year-old said April 26 in an interview with Page Six. "The regret of not starting it 10 years ago."

He continued, "I feel amazing! Like, why didn't I do this sooner? Maybe it wasn't the right time."

And he isn't the only celebrity singing Ozempic's praises—though others have warned against it. Keep reading to see what everyone in Hollywood is saying about Ozempic, good or bad. 

The Jon & Kate Plus 8 alum told Page Six in April 2024 that he lost 32 pounds in two months after taking injections of semaglutide, the generic form of Ozempic.

"You know what's annoying?" he said. "The regret of not starting it 10 years ago."

The Pioneer Woman star shared on her blog in March 2024 that her 50-pound weight loss in 2022 was not due to taking Ozempic or similar medications.

She added, "Not you'll never hear a second of judgment from me about people who choose that direction!"

In August 2023, the 30 Rock alum said on Today With Hoda and Jenna that he lost weight on Ozempic because it supressed his appetite.

In March 2024, his health journey appeared to take a surprising turn. "I've learned to out-eat Ozempic," he said on The Tonight Show Starring Jimmy Fallon. "I gained 40 pounds."

Later that month, he clarified to E! News that he was joking, adding, "Ozempic did great by me and I was glad to use it."

“I can’t speak medically about it, but I do know that there’s so much information about what’s working and what’s not,” she shared during part of an interview with Fox News Digital. “I think that Ozempic has some great benefits, and I also think it has some dangers.”

The Beverly Hills, 90210 tried the drug to help her slim down after giving birth to her son Beau in 2017.

"I tried Ozempic and it didn't work for me," she shared in an April 2024 episode of her misSPELLING podcast, "so I went on Mounjaro, which did do the trick and I did lose weight."

"I think it's very important we understand certain medications are made for certain people," she told E! News' Francesca Amiker, "and to not take that away just for glamazon purposes."

Raven continued, "Do what you gotta do, just make sure you save the medication for the people who actually need it."

The Talk U.K. host revealed in September 2023 that she shed 42 pounds after using Ozempic earlier in the year.

"Whatever you choose is up to you," she exclusively told E! News. "It's not a dirty little secret when you've taken something to help you lose weight, which is perfectly fine."

She added, "We don't have to bulls--t."

Sharon's daughter has also weighed in on the Ozempic trend.

"I think it's amazing," the Fashion Police alum told E! News in January 2024. "There are a million ways to lose weight, why not do it through something that's isn't as boring as working out?"

The Titanic star, who was once a target for tabloids when it came to her weight, shared what she thought about the weight loss trend.

"I actually don't know what Ozempic is," Kate admitted to The New York Times Magazine in an interview published March 3. "All I know is that it's some pill that people are taking or something like that."

"Oh, my God," Kate remarked after learning about the drug. "This sounds terrible."

The Hills star revealed in December 2023 that she'd recently lost 22 pounds—without taking Ozempic. "There's no shortcuts in life. And if you're taking that shortcut, I don't know," she told Page Six of other celebrities using the drug. "I don't want to name names or get into it, it's just nothing I would ever do."

Heidi noted, "I want something that is sustainable. I want something that does also require hard work."

The Trainwreck star did not hold back when she called out celebrities for not being honest about using Ozempic as a weight loss tool during her June 8, 2023 appearance on Watch What Happens Live. 

"Everyone and their mom is gonna try it. Everyone has been lying saying, 'Oh, smaller portions,'" she told Andy Cohen, who has also ppublicly weighed in on the Ozempic craze multiple times. "Like, shut the f--k up. You are on Ozempic or one of those things, or you got work done. Just stop."

Schumer, who has been open about her past medical procedures, added, "Be real with people. When I got lipo, I said I got lipo."

She admitted to becoming "immediately invested" in Ozempic last year, but explained that it was not "livable" for her to take the Type 2 diabetes drug and hindered her ability to spend time with her 4-year-old son Gene. 

"I was one of those people that felt so sick and couldn't play with my son," Schumer recalled. "I was so skinny, and he's throwing a ball at me and [I couldn't]."

"People have a mixed feeling about interventions like this," Dr. Drew exclusively told E! News at Fox's Special Forces: World's Toughest Test season two event in Los Angeles on Sept. 12, 2023. "They're tantalized by it, but on the other hand, they have this weird judgment."

He continued, "If we have a medication that can be helpful, by all means, people should be encouraged to think about it."

Forget winter, a hot take is coming.

The Game of Thrones alum was not shy when it came to sharing her opinion about Ozempic and its advertisements.

In an April 5, 2023 Instagram Story, the actress reposted a tweet from writer Sophie Vershbow that read, "The Ozempic ads plastered across the Times Square subway station can f--k all the way off." One ad featured in Vershbow's Twitter photos read, "One shot to lose weight," while another offered similar text, "A weekly shot to lose weight."

Turner adding her own commentary, writing, "WTF."

Ozempic maker Novo Nordisk previously told E! News that the drug is not FDA-approved for chronic weight management.

"While we recognize that some healthcare providers may be prescribing Ozempic for patients whose goal is to lose weight, Novo Nordisk does not promote, suggest, or encourage off-label use of our medicines and is committed to fully complying with all applicable U.S. laws and regulations in the promotion of our products," the Danish pharmaceutical company said in a statement. "We trust that healthcare providers are evaluating a patient's individual needs and determining which medicine is right for that particular patient."

Ozempic is no laughing matter for the comedian. Handler revealed her "anti-aging doctor" prescribed her the medication without realizing what the drug was.

"I didn't even know I was on it," she said during the Jan. 25, 2023 episode of Call Her Daddy. "She said, 'If you ever want to drop five pounds, this is good.'"

But while she tried the drug, Handler noted that she didn't like how it made her feel.

"I came back from a vacation and I injected myself with it," she recalled. "I went to lunch with a girlfriend a few days later, and she was like, 'I'm not really eating anything. I'm so nauseous, I'm on Ozempic.' And I was like, 'I'm kind of nauseous too.' But I had just come back from Spain and was jet-lagged."

Ultimately, Handler stopped using the drug because it wasn't medically necessary for her, adding that she gave away the remaining doses to friends.

"I've injected about four or five of my friends with Ozempic, because I realized I didn't want to use it because it was silly," she said. "It's for heavy people. I have people coming over to my house, and I'm like, 'OK, I can see you at 1, I can see you at 2.'"

KoKo clapped back when commenters on Instagram speculated that she was taking Ozempic. 

"Let's not discredit my years of working out," Kardashian wrote on a January 2023 post. "I get up 5 days a week at 6am to train. Please stop with your assumptions. I guess new year still means mean people."

In addition to embracing the weight-loss drug, Dubrow actually revealed in January 2023 he temporarily used Mounjaro to learn how it affects the body.

"I thought it was amazing," the Botched star shared. "I didn't have that much weight to lose. But I wanted to try it because so many of my patients were on it and I wanted to see what it was like when you're not diabetic and you only have 10 to 15 pounds to lose."

Although Dr. Dubrow didn't disclose how much weight he lost or how long he took the medication for, he confirmed he's no longer using it.

"I thought, 'You know what, I kind of want to get my appetite back,'" he explained the reason for quitting the medication, noting he also experienced "low-grade nausea."

The Real Housewives of Beverly Hills star got real about claims that she was taking the medication after her followers on social media took notice of her weight loss earlier this year.

Richards wrote back to one user under a Jan. 5, 2023 snap on Instagram of herself and her girlfriends after a workout, "I am NOT on ozempic." In another response, Richards added, "Never have been."

That wouldn't be the last time the Bravo star shot down the rumors, reiterating that she is "NOT taking" the medication under a Jan. 16 post on Instagram by Page Six. 

After fans questioned whether or not she was taking Ozempic, Jessica set the record straight.

Oh Lord," she told Bustle in an interview published July 6, 2023. "I mean, it is not [Ozempic], it's willpower. I'm like, do people want me to be drinking again? Because that's when I was heavier. Or they want me to be having another baby? My body can't do it."

Nassif echoed his Botched costar in giving the drug two thumbs up.

"Just like he's telling everyone, no Ozempic-shaming," he exclusively told E! News Feb. 1. "I'm OK with it. I'm OK with Terry and—actually a lot of my friends I saw this last weekend—they all look incredible. Health-wise, they felt better, their blood sugars came down, their blood pressure came down. All of this can hopefully help with longevity, you just have to do it the right way."

In fact, the famed plastic surgeon said taking Ozempic potentially has other benefits outside of weight management."We're looking into Ozempic more also as an anti-aging treatment for the future," Nassif explained. "So, there's going to hopefully be some good things the more we learn about all these semaglutides and the different products. 

This Shah isn't shy about her Ozempic use. 

Gharachedaghi didn't "see a reason to hide" being on the medication when discussing her health journey, telling Entertainment Tonight in May 2023 that she would prefer to "just talk about it because there's so many people out there who want to do the same thing or they want to learn about what you did."

Of her 30-pound weight loss due to her experience with Semaglutide—the generic version of the weight-loss drug—the Shahs of Sunset star explained, "Obviously, I didn't look like this two months ago. So..I would be a liar to say I quit drinking alcohol and you know all of a sudden started working out like some people like to say."

Gharachedaghi went on to note that she still has an appetite, saying, "I'm actually a little hungry. Look I'm gonna go smoke a little pot and I'm gonna eat definitely."

The influencer said that using Ozempic to treat her type 2 diabetes negatively affected her overall health. 

"It was brand new, just got FDA approved, no one knew about it and I was so scared," Bader recalled on the Jan. 12, 2023 episode of the Not Skinny But Not Fat podcast. "They said I need this. And I had a lot of mixed feelings."

After she went off the drug, Bader—who has been open about her battle with binge eating—said it caused a cycle of "bad binging."

"I saw a doctor, and they were like, 'It's 100 percent because you went on Ozempic,'" she explained. "It was making me think I wasn't hungry for so long. I lost some weight. I didn't want to be obsessed with being on it long term. I was like, 'I bet the second I got off I'm going to get starving again.' I did, and my binging got so much worse. So then I kind of blamed Ozempic."

Forget shedding for the wedding because The Real Housewives of New Jersey cast member admitted she was taking Ozempic to lose weight prior to filming the season 13 reunion. 

During the April 4, 2023 episode of Watch What Happens Live with Andy Cohen, Catania confirmed she had been taking the antidiabetic medication because she didn't want to be "looking any bigger than anyone else," at the taping, explaining, "I got on the bandwagon." She then joked that "not one" of her co-stars wasn't also taking Ozempic and said the only side effect she was experiencing was that she was "just not hungry."

The tennis legend—who has been open about her struggles with an eating disorder—expressed her reluctance in trying diabetes medication solely for weight loss purposes. 

"With the new injections, the Ozempics of the world, it's very interesting because my doctor wants me to try it," she shared in an April 2024 episode of Lemonada Media's Wiser Than Me podcast. "I don't want to lose weight fast because I think it looks horrible. I don't think it's healthy."

However, she noted that she has "taken a few injections"

Tim McGraw and Faith Hill's daughter first opened up about taking the diabetes drug when she shared her PCOS diagnosis in March 2022. 

"To get the correct diagnosis you would need 2 out of the 5 characteristics of PCOS and I had 4," she wrote on Instagram at the time. "During my appointment with my endocrinologist I realized that may have been a factor in my issues with weight, so we decided to try a medicine to regulate my body more normally and create the tools to continue to keep my body and myself healthy as I get older."

Gracie offered an update on her health journey in a June 5 post after a commenter called out her alleged use of Type 2 diabetes medication.

"I did use Ozempic last year, yes," she wrote. "I am now on a low dose of Mounjaro for my PCOS as well as working out. No need to accuse when I have been open about it."